TBIOL 130 Clark Atlanta University Macromolecules Questions

Module I Pencil & Paper Homework Assignment
Winter 2023
Alcohol Reactions Reactions
Ch 9 (Smith 6e)
Reading
Topic
9.3
9.6
Naming Alcohols
Synthesizing Alcohols, Ethers,
Epoxides
Dehydration of Alcohols
Alcohols to Alkyl Halides
Tosylates
Rxns of Ethers
Thiols and Sulfides
Epoxides
Mixed Practice
Synthesis
Problems
From Smith unless specified
9.9.8-10
9.11-12
9.13
9.14
9.15
9.16-18
Optional
Problems
9.54a, 9.55
9.44a,c; 9.45b,c,d,f;
9.48, 9.50, 9.51
9.65
9.59a,d; 9.61a,c;
9.43,
9.66
9.64
Complete the homework problems listed above. You may choose to do optional problems but those are
not required.
Use the answer key provided to grade your homework assignment using a different color pen. Mark
problems that are correct (star or check mark) and those that are incorrect (x or slash). Rework any
incorrect problems.
Grade will be based on completeness, self-grading, and occasionally on the ability to explain a problem
to classmates in a table group.
Problem Set II
Macromolecules
TBIOL 130 (Winter ‘23)
Name:
Score:
Answer the following questions to the best of your ability; this exercise is worth 30 points and must be uploaded to Canvas
by midnight on Friday of Week 3 (Jan. 20th). You may work together with a group to complete this exercise, but everyone
must submit their completed problem sets separately. Please note that “work together with a group” does not mean that
you can submit identical answers. In other words, you can consult with your peer(s) on the answer (or the means to come
up with the answer) but you need to answer the questions in your own words.
You may provide your answers in a separate file or within this worksheet (save as a .pdf file) but for the latter, remember
to TYPE YOUR ANSWERS IN RED (or another color of your choice)!
1. (5 points) For the following questions, match the macromolecule on the left (a-d) with the description on the right
(1-10). Please note that all terms will be used at least once. While some descriptions may have more than one
answer, you only need to list one.
a.
b.
c.
d.
Nucleic Acids
Polysaccharides
Lipids
Protein
1.
A macromolecule that is considered amphipathic.
2.
The monomers for this group of macromolecules have three attached
phosphates.
For this macromolecule, each monomer has an amine and carboxyl group.
3.
4.
5.
6.
The macromolecule chitin is part of the cell wall in fungal cells and provides
structural support.
A macromolecule that relies on a glycerol molecule as its backbone.
7.
The monomers for this macromolecule are used as an “energy currency” within
the cell.
This macromolecule is used as a long-term energy store.
8.
Ribose is a monomer in this group of macromolecules.
9.
A macromolecule that must be “folded” into a 3D shape before it can be
referred to by its name.
10. An mRNA molecule.
2. (1 point) Two monosaccharides are joined together by a covalent bond via
reactions, however, disaccharides can be split using
reactions.
BONUS (1 point): Consider the synthesis of lipids and their functional
role in the formation of lipid bilayers (shown). A) Briefly explain why
lipids are not considered a “traditional” polymer and then, B) speculate
what effect this will have on the structure of the bilayer (i.e. are cellular
membranes considered rigid or fluid structures? How might this be
explained by the fact that lipids are not true polymers?).
Problem Set II
Macromolecules
TBIOL 130 (Winter ‘23)
3. (2 points) Below is an image of two nucleotides. Draw the resulting dinucleotide product and label the
phosphodiester bond.
a. (1 point) What molecule is released after the nucleotides are linked via a phosphodiester bond?
b. (2 points) What do the terms, 5’ and 3’, reference on a DNA nucleotide? What chemical groups can be
found at these positions of the DNA nucleotide?
c. (2 points) Is the figure above showing DNA or RNA? How do you know?
d. (1 point) What does Base mean in the above figure?
Problem Set II
Macromolecules
TBIOL 130 (Winter ‘23)
4. (2 points) Below is an image of two monosaccharides. Draw the resulting disaccharide product and label the
glycosidic linkage.
a. (1 point) What molecule is released after the monosaccharides are linked via a glycosidic bond?
b. (2 points) If the disaccharide is considered hydrophilic, draw a water molecule and show how it can
hydrogen bond with the disaccharide. If not, write “hydrophobic” next to your disaccharide.
5. (1.5 points) Monosaccharides have the general chemical formula CnH2nOn. Write the chemical formula for each
of the below monosaccharides.
a. (1.5 points) What do you notice about the chemical formulas you wrote? Briefly explain how this can
be.
Problem Set II
Macromolecules
TBIOL 130 (Winter ‘23)
6. (2 points) Below is an image of two amino acids. Draw the resulting dipeptide product and label the peptide
bond.
a. (1 point) What molecule is released after the amino acids are linked via a peptide bond?
b. (2 points) What do the terms, N-terminus and C-terminus, reference on a polypeptide sequence? What
chemical groups can be found at these positions of the polypeptide?
7. (3 points) Which of the R groups in the amino acids shown below match the following descriptions (write the
letter). Molecules may be used once, more than once, or not at all. If none of the molecules fit the description,
write N/A.
Polar:
Nonpolar:
Acidic:
Basic:
Hydrophilic:
Hydrophobic: