Week 1 NR507 Discussion Question Response SS

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The condition that applies to my name is Systemic Lupus Erythematosus (SLE). Systemic Lupus Erythematosus (SLE) is a disease where the body’s immune system starts attacking its own tissues, causing inflammation and damage in many parts of the body. The immune system usually protects us from infections, but in lupus, it becomes overactive and starts harming healthy tissues. This damage can affect organs like the skin, joints, kidneys, and heart. It’s not fully understood why this happens, but a mix of genetics, environment, and the immune system’s malfunction are thought to contribute to the disease (Jariwala et al., 2021).

Wilbur’s symptoms may be linked to SLE. He has a rash on his chest and back that is purple in color, which could be a sign of the skin problems that people with lupus often get. One common rash in lupus patients is called the “butterfly rash,” which looks like a red rash across the nose and cheeks. Although Wilbur’s rash is not exactly like that, the color and chronic nature (lasting for months) could still point to lupus-related skin issues. The white coating on Wilbur’s tongue could be a sign of a fungal infection called thrush. People with lupus often have a weakened immune system because of the disease or the medicines they take for it, making them more prone to infections. Wilbur’s comment about being “sick a lot lately” also fits with lupus, which can cause people to feel unwell or experience infections more often due to the immune system being out of balance.

Tests that would help confirm SLE include:

1. Antinuclear Antibody (ANA) Test: This is a blood test that checks for autoantibodies. In lupus, the body makes these antibodies that attack its own cells. A positive ANA test is common in lupus, but it can also be positive in other diseases.
2. Anti-dsDNA and Anti-Smith Antibodies: These are more specific tests for lupus. If these are positive, they are a strong indication of lupus.
3. Urinalysis: This test looks at the urine and helps check for kidney problems, which are common in lupus. If Wilbur has protein in his urine, it could be a sign of kidney involvement (Kahlenberg, et al., 2023).
4. Blood Tests (CBC and Complement Levels): Blood tests can check for anemia (low red blood cells) and low levels of certain proteins (called complement), which are common in active lupus.

References:

Jariwala, P., Sethi, S., & Palaian, S. (2021). Systemic Lupus Erythematosus: Pathophysiology, Diagnosis, and Treatment. Journal of Clinical Rheumatology, 27(5), 213-223. https://doi.org/10.1097/RHU.0000000000001462

Kahlenberg, J. M., & Choi, J. (2023). Advances in the Immunology of Lupus and Implications for Treatment. Frontiers in Immunology, 14, 724546. https://doi.org/10.3389/fimmu.2023.724546